Downtown hotels in Rochester, United States

Carefully selected hotels offering comfort and convenience in Rochester, United States
Check-in
06Sept2025Select date
Check-out
07Sept2025Select date
Rooms and Guests2 Guests, 1 Room
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1-20 out of 28
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  • Popularity: high to low
9.0
Perfect
MapAdjacent to Mayo Clinic0m
  • Indoor pool and fitness center
  • On-site restaurant with diverse menu
  • Direct access to Mayo Clinic
  • Indoor Pool
  • On-site Dining
  • Fitness Center
Hotel connected to top-rated healthcare and amenities
FromUS$ 109 /nightSelect
MapHeart of Downtown Rochester300m
  • Rooftop indoor pool
  • Modern American dining
  • Direct access to Mayo Clinic
  • Indoor pool
  • Fitness center
  • Onsite dining
Historic hotel with modern amenities near Mayo Clinic
FromUS$ 76 /nightSelect
MapNear Mayo Clinic200m
  • Indoor pool with kiddie area
  • Award-winning Twigs Tavern restaurant
  • On-call shuttle to Mayo Clinic
  • Indoor pool
  • Fitness center
  • Game room
Hotel offering tailored services for Mayo Clinic visitors
FromUS$ 93 /nightSelect
7.0
Very good
MapNear Mayo Clinic1.3km
  • Indoor pool with water slides
  • On-site dining options available
  • Complimentary shuttle service provided
  • Indoor Pool
  • Fitness Centre
  • Spa Jacuzzi
Family-friendly hotel with recreational amenities and dining
FromUS$ 69 /nightSelect
5.4
Guest rating
MapClose to St Mary's Hospital300m
  • Indoor pool with waterslide
  • Onsite Famous Dave's Bar-B-Que
  • Complimentary shuttle to Mayo Clinic
  • Indoor Pool
  • Spa Services
  • Business Center
Family-friendly hotel with exceptional medical access
FromUS$ 63 /nightSelect
MapAdjacent to Saint Marys Hospital50m
  • Complimentary hot breakfast served daily
  • Convenient shuttle service to Mayo Clinic
  • Indoor swimming pool and whirlpool available
  • Indoor pool
  • Fitness center
  • 24-hour store
Hotel designed for extended stays near major medical facilities
FromUS$ 145 /nightSelect
MapNear Mayo Clinic300m
  • Direct access to Mayo Clinic via subway
  • Complimentary breakfast offered to guests
  • Comfortable beds with convenient room layouts
  • Free parking
  • Complimentary breakfast
  • Laundry services
Hotel providing convenient access for medical visitors
FromUS$ 125 /nightSelect
MapNear Mayo Clinic700m
  • Indoor pool and fitness centre available
  • Complimentary breakfast with hot options
  • Kitchen facilities in spacious rooms
  • Indoor pool
  • Fitness centre
  • Kitchenettes
Hotel with family-friendly amenities and dining options
FromUS$ 149 /nightSelect
MapAcross from Mayo Clinic200m
  • Rooftop pool with city views
  • Onsite dining and bar
  • Modern fitness center available
  • Rooftop pool
  • Fitness center
  • Onsite dining
Hotel featuring modern amenities with rooftop leisure options
FromUS$ 205 /nightSelect
MapConnected to Mayo Clinic0m
  • Rooftop bar with craft cocktails
  • Modern American cuisine at Crave
  • Pet-friendly rooms available
  • Fitness Center
  • On-site Dining
  • Transportation Service
Boutique hotel with modern decor near vibrant attractions
FromUS$ 119 /nightSelect
MapAcross from Saint Marys Hospital0m
  • Indoor pool with whirlpool
  • On-site dining with Starbucks
  • Free shuttle to Mayo Clinic
  • Indoor Pool
  • Fitness Center
  • On-site Restaurant
Hotel with convenient access to medical facilities and dining
FromUS$ 140 /nightSelect
MapNearby restaurants and stores200m
  • Indoor pool and fitness center
  • Complimentary breakfast buffet available
  • Free shuttle service to Mayo Clinic
  • Indoor Pool
  • Fitness Center
  • Business Center
Hotel with convenient access to Mayo Clinic facilities
FromUS$ 109 /nightSelect
MapMayo Clinic proximity1.0km
  • Connected to Mayo Clinic via underground walkways
  • Indoor pool and fitness center available year-round
  • On-site dining at Salute Wine Bar & More
  • Indoor Pool
  • Fitness Center
  • Valet Parking
Hotel connected to Mayo Clinic with upscale accommodations
FromUS$ 190 /nightSelect
Central Rochester downtown250m
  • Indoor pool for year-round relaxation
  • Direct access to Mayo Clinic via skybridge
  • Spacious rooms with full kitchens available
  • Heated pool
  • Fitness center
  • On-site laundry
Premier hotel with luxury apartments near Mayo Clinic
FromUS$ 150 /nightSelect
MapProximity to Mayo Clinic1.2km
  • Indoor pool and hot tub area
  • Free shuttle service for hospital visits
  • Complimentary breakfast with diverse options
  • Indoor pool
  • Fitness center
  • Complimentary breakfast
Hotel offering easy access to medical facilities and family-friendly amenities
FromUS$ 130 /nightSelect
MapDirect access to Mayo Clinic350m
  • Complimentary evening social hour
  • Functional kitchen in every room
  • Accessible direct walk to Mayo Clinic
  • Fitness center
  • Rooftop patio
  • Business center
Hotel offering extended stay suites near Mayo Clinic
FromUS$ 164 /nightSelect
MapNear Mayo Clinic300m
  • Complimentary hot breakfast buffet
  • Indoor swimming pool and hot tub
  • Shuttle service to medical facilities
  • Indoor Pool
  • Heated Parking
  • Fitness Center
Medical center hotel offering comfort and amenities
FromUS$ 125 /nightSelect
MapNear Mayo Clinic300m
  • Indoor pool with whirlpool
  • Complimentary hot breakfast
  • Pet-friendly rooms available
  • Indoor pool
  • Fitness center
  • On-site bar
Extended-stay hotel with versatile family-friendly offerings
FromUS$ 168 /nightSelect
MapNear Saint Marys Hospital50m
  • Complimentary breakfast included for guests
  • Free shuttle to Mayo Clinic locations
  • Convenient location near Saint Marys Hospital
  • Fitness Center
  • Business Centre
  • Outdoor Patio
Hotel offering tailored services for extended stays
FromUS$ 132 /nightSelect
MapClose to Mayo Clinic200m
  • Rooftop terrace with city views
  • Two onsite restaurants available
  • Located near Mayo Clinic
  • Indoor pool
  • Fitness center
  • Executive lounge
Hotel with rooftop views and premium dining options
FromUS$ 265 /nightSelect
  • 1
  • 2

Hotel Price Range in Rochester

From budget-friendly stays to luxury downtown properties—find a hotel that fits your travel style

⬆️ The highest price
US$ 439
⬇️ The lowest price
US$ 63
💸 Average price for
4-star hotels
US$ 194
3-star hotels
US$ 136

Downtown hotels in Rochester

Rated by real guests over the past 12 months

FAQs about downtown hotels in Rochester

Find answers to common questions to plan your trip

What are the cheapest downtown hotel options in Rochester?
The cheaper options include Super 8 By Wyndham Rochester Mayo Clinic Area and Quality Inn & Suites Mayo Clinic Area, typically starting at around $80 per night. Prices vary by season.

Downtown Rochester Hotel Insights

This guide provides essential information on two hotels downtown in Rochester, focusing on key details like pricing, attractions, and seasonal trends to help you make informed lodging decisions.

Typical nightly rates range from $120 to $250.

There are 2 downtown hotels evaluated.

Peak travel seasons are summer and fall.

Local taxes/fees total approximately 12%.

Hotels are within 1 mile of the Strong National Museum of Play.

Check-in
06Sept2025Select date
Check-out
07Sept2025Select date
Rooms and Guests2 Guests, 1 Room