21C MUSEUM HOTEL LOUISVILLE, Louisville

21C Museum Hotel Louisville - Contemporary Art Museum Hotel with Bourbon-Inspired Dining and Downtown Cultural Access

Located in historic Whiskey Row, this 5-star Louisville hotel merges a 9000-square-foot contemporary art museum with a 91-room boutique property. 21C Museum Hotel features the acclaimed Proof on Main restaurant, specializing in Ohio River Valley cuisine under Executive Chef Cody Stone. Guest rooms, housed in former bourbon and tobacco warehouses, include premium Bryte Restorative Sleep Beds, flat-screen TVs, minibars, and coffee makers, with some rooms offering Ohio River views. Four private galleries accommodate meetings and events for 10 to 60 guests. The property hosts regular art exhibitions, installations, and cultural events including the Fork & Bottle dinner series featuring regional distillers. 21c Museum Hotel Louisville stands within a half-mile radius of the Kentucky Museum of Art & Craft, Frazier International History Museum, and Muhammad Ali Center. The free ZeroBus, accessible two roads from the hotel, connects guests to downtown attractions like Slugger Field and Waterfront Park.

Pros

Regular cultural programming includes guest distiller events and art performances

Historic warehouse architecture preserved throughout the property

Dedicated event staff provides customized catering menus

On-site contemporary art museum with rotating exhibitions

Cons

Downtown location can be busy during major events and festivals

Some rooms face busy city streets